Papasavvas et al. and Y.H.H.) However, he developed blurred vision, red eye, and conjunctival hyperemia of the left eye 14 days after the second dose of the vaccine. Acute corneal endothelial graft rejection following COVID-19 vaccination. BCVA improved to 20/25 with a clear cornea one week later. Moher D., Liberati A., Tetzlaff J., Altman D.G. Tan DT, Dart JK, Holland EJ, Kinoshita S. Acute corneal endothelial graft rejection with coinciding COVID-19 infection, Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients, Stromal rejection in a deep anterior lamellar keratoplasty following influenza vaccination, Corneal allograft rejection associated with herpes zoster recombinant adjuvanted vaccine. The other case, an 83-year-old woman, underwent DMEK 6years before BNT162b2 administration. Dias L., Soares-dos-Reis R., Meira J., Ferro D., Soares P.R., Pastor A., Gama G., Fonseca L., Fagundes V., Carvalho M. Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine. MRI of the brain and orbit was unremarkable. Based on the OR from different studies, it is highly unlikely that Bells palsy is associated with COVID-19 vaccination and if at all, the pathophysiological process for facial nerve palsy post COVID-19 vaccination needs to be hypothesized and proven. Multiple evanescent white dot syndrome: findings from a large Northern California Cohort. Updated Covid vaccines need to target XBB omicron variants this fall, FDA staff says . Maleki et al. Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; moc.liamtoh@90911tnecniv. Diabetic retinopathy. On the other hand, Bayas et al. Researchers believe that eye-related effects after COVID-19 vaccination may happen due to the body's immune response to the vaccine. FOIA HLA-B27 testing returned negative. The study found the subjects presentation to fit the diagnostic criteria for autoimmune/inflammatory syndrome induced by adjuvants (ASIA),66 also known as Shoenfelds Syndrome. In this study, we aimed to review all reported ocular side effects of the available COVID-19 vaccines. However, evidence has shown that during transcription, alternative splice events might cause the formation of C-terminally truncated, which may lead to formation of soluble spike protein. reported a 27-year-old male who developed headache associated with eye floaters and vomiting 48 h after receiving the first dose of the ChADO1 COVID-19 vaccine. The U.S. is more equipped than ever against . 8600 Rockville Pike N. Engl. A 33-year-old male presented with blurring of vision and metamorphopsia 69h after receiving the first dose of BNT162b2 and was diagnosed with central serous chorioretinopathy.27 He had a previous ocular history of mild hyperopic refractive error. Among them, four (0.5%) participants had blurring of vision and seven (0.87%) participants had eye pain within six weeks after receiving the vaccine [40]. We excluded 5 of these studies due to reports not being retrieved, leaving 48 articles suitable for inclusion. These soluble spike variants may induce thrombotic events via an antibody-mediated mechanism when binding to ACE2-expressing endothelial cells in blood vessels [41,45]. The reported entities appear to overlap with the ocular manifestations of COVID-19 itself, suggesting a common pathway between virus and vaccine-mediated immune response in humans. Although pink eye seems to be one of the more common eye symptoms, it occurs in a low percentage of people. She manifested a severe reactivation of VKH 6weeks after receiving the second dose of the BNT162b2 vaccine. The other patient was a 56-year-old male with a history of bilateral keratoconus who underwent PKP 25 and seven years ago in the right and left eyes, respectively. However, the headache worsened, and new homonymous hemianopia occurred the following day. Itching Discharge It's important to note that while eye symptoms have been reported in relation to positive COVID-19 cases, it is uncommon for it to be the only symptom. The mean age of the patients was 42.9 (range 1860) years old. A new, sensible plan for fall covid boosters is taking shape. Reports on graft rejection after other viral vaccinations are scarce.6264. Multi-luminance-flicker electroretinogram revealed defective areas in the inferotemporal macula and temporal macula in the right and left eyes, respectively. No description of ocular symptoms or ophthalmic investigations were included in the study. Although vaccines against COVID-19 have been developed and approved under emergency use authorization, various adverse events have also been reported after COVID-19 vaccination. The patient opted to receive his second dose after being counselled for the possible association between the first dose of vaccination and the acute transplant rejection. Fowler N, Mendez Martinez NR, Pallares BV, Maldonado RS. The patients characteristics were reviewed in six articles. reported a 27-year-old female who took oral contraceptives and developed an acute paracentral scotoma after receiving the first dose of the ChAdO1 COVID-19 vaccine [18]. In the remaining four articles, all subjects received the BNT162b2 vaccine. and vaccine who presented seven days after vaccination with bilateral eye redness and pain . Kadali et al. Similarly, antibodies against spike proteins and activated Th1 cells can cross-react with proteins and antigens in the outer retinal layers, retinal pigment epithelial cells, and large arteries, which may induce AZOOR and AAION [26]. Right eye regraft was performed due to late endothelial failure 10 months previously. In fact, the recommendations provided were to vaccinate MS patients to alleviate the disease burden of COVID-19. official website and that any information you provide is encrypted Visual acuity was reinstated to 6/6 bilaterally in eleven days. At final follow-up, complete resolution was achieved in all but two eyes, which showed significant improvement. Subtle capillary dropout was also noted on OCT angiography. NXL, BKB, MDS, and RA wrote the manuscript. A systemic search was performed on 22 August 2021 through Embase, Medline, and Cochrane Library for publications on ocular manifestations after COVID-19 vaccination. Lundstrom K., Barh D., Uhal B.D., Takayama K., Aljabali A.A.A., Abd El-Aziz T.M., Lal A., Redwan E.M., Adadi P., Chauhan G., et al. Rare ocular side effects have been noted after COVID-19 vaccination By Danah Albreiki, MBBS Comprehensive Ophthalmology Comments Views 9522 Review of: Ocular adverse events after COVID-19 vaccination Ng X, Betzler B, Testi I, et al. Covid attacks the retina to cause eye problems including black spots mRNA vaccines can also stimulate innate immunity through toll-like receptors, which are related to reactivation and maintenance of herpesviruses in the host [12]. Crnej A., Khoueir Z., Cherfan G., Saad A. Acute macular neuroretinopathy following COVID-19 vaccination. FOIA Phylactou M., Li J.P.O., Larkin D.F.P. It's known that vaccines are able to cure or help long standing issues relating to covid. The authors have no relevant financial or non-financial interests to disclose. OCT revealed massive subretinal fluid involving the macula in the right eye. The mRNA is delivered in lipid nanoparticles and induce the production of proinflammatory cytokines, such as interferon gamma (IFN), antigen-specific CD4+ and CD8+ T cell responses, and anti-spike neutralizing antibody. Mudie L.I., Zick J.D., Dacey M.S., Palestine A.G. Panuveitis following Vaccination for COVID-19. Kumari S, Anand R, Sambyal B, Singh Y, Rangappa P, Jha SK. Jackson L.A., Anderson E.J., Rouphael N.G., Roberts P.C., Makhene M., Coler R.N., McCullough M.P., Chappell J.D., Denison M.R., Stevens L.J., et al. All authors contributed to the intellectual development of this paper. June 26, 2023 Updated: June 26, 2023 9:45 a.m. New COVID vaccines expected this fall will . Abdominal computed tomography (CT) revealed bilateral adrenal hemorrhages and a subcapsular renal hematoma. Eye problems that could be related to COVID - All About Vision Furthermore, of the published cases with clear ocular pathology demonstrated on examination and investigation, most recovered well with swift initiation of treatment. MacNeil J.R., Su J.R., Broder K.R., Guh A.Y., Gargano J.W., Wallace M., Hadler S.C., Scobie H.M., Blain A.E., Moulia D., et al. Licensee MDPI, Basel, Switzerland. In our literature review, there were seven patients with uveal manifestations. However, the relative rarity of AMN and the temporal association between the vaccine administration and the onset of the disease should be taken into consideration. Careers, Unable to load your collection due to an error. reported a 47-year-old female with a history of iron-deficiency anemia due to adenomyosis and oral contraceptives. 4 Ways COVID Leaves Its Mark on the Eye - American Academy of Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine, Bilateral multifocal choroiditis following COVID-19 vaccination. The patients characteristics were reviewed in four articles. The mRNA vaccines, including BNT162b2 and mRNA-1273, contain codon-optimized sequences for spike protein synthesis and use the authentic signal sequence for its biosynthesis [41]. After full-text evaluation, 18 studies were excluded due to no relevant and 1 study was excluded due to unknown vaccine. COVID Can Cause Strange Eye and Ear Symptoms Ocular Manifestations after Receiving COVID-19 Vaccine: A Systematic Review The coronavirus disease 2019 (COVID-19) pandemic has had profound and lasting consequences since 2019. Vision-Threatening Ocular Adverse Events after Vaccination against Coronavirus Disease 2019. Wasser et al. FOIA Other possible causes of thrombosis include spike protein interactions with different C-type lectin receptors, heparan sulfate proteoglycans, and the CD147 receptor. Castelli et al. There remains a larger question of elucidating the mechanisms involved in a maladaptive immune response and identifying the susceptible individuals for closer follow up. The relationship between adenoviral vector vaccines and all of the ocular symptoms mentioned should be further investigated. Laboratory investigations revealed thrombocytopenia and high D-dimer levels. independently screened all titles and abstracts based on the inclusion criteria and subsequently retrieved all relevant full-text articles for suitability assessment. Overall, the benefits of COVID-19 vaccination both at an individual and a population level far outweigh the risks of ocular complications. A diagnosis of bilateral simultaneous acute endothelial graft rejection was made. Four articles described corneal graft rejection soon after receiving a COVID-19 vaccination.25,34,36,43 Phylactou et al.34 reported two cases of allograft rejection following Descemets membrane endothelial keratoplasty (DMEK); both were female. Brain MRI with venography revealed CVST with right frontal subarachnoid hemorrhage and a cortical venous infarct. and transmitted securely. Collela et al.24 and Repajic et al.38 provided detailed expositions of the signs and symptoms that led to a diagnosis of Bells palsy in COVID-19 BNT162b2 vaccine recipients. Federal government websites often end in .gov or .mil. the contents by NLM or the National Institutes of Health. However, she was also diagnosed with asymptomatic COVID-19 shortly after the onset of ocular symptoms [24]. Brain magnetic resonance imaging (MRI) revealed CVST and right internal jugular vein thrombosis [37]. Logunov D.Y., Dolzhikova I.V., Zubkova O.V., Tukhvatulin A.I., Shcheblyakov D.V., Dzharullaeva A.S., Grousova D.M., Erokhova A.S., Kovyrshina A.V., Botikov A.G., et al. However, as the VKH reactivation was reported six weeks after receiving the second dose of vaccination, it is difficult to establish a temporal association between COVID-19 vaccination and VKH reactivation based on this single case report. A healthy 59-year-old female presented with isolated abducens nerve palsy following a febrile episode two days after receiving the BNT162b2 vaccine.39 No details on the persistence of the palsy were provided. Haseeb AA, Solyman O, Abushanab MM, Abo Obaia AS, Elhusseiny AM. In total, 31 studies were included in our systemic review and classified into eyelid, cornea and ocular surface, retina, uvea, nerve, vascular thrombosis, and others according to different parts of eye and adjacent tissues. All these factors may contribute to CSCR [21]. Wolf M.E., Luz B., Niehaus L., Bhogal P., Bzner H., Henkes H. Thrombocytopenia and intracranial venous sinus thrombosis after covid-19 vaccine astrazeneca exposure. Eye Floaters after COVID? : r/EyeFloaters - Reddit The Pfizer-BioNTech (BNT162b2)14 and Moderna (mRNA-1273)15 vaccine trials suggest an imbalance in the incidence of Bells palsy following vaccination compared with the placebo arm of each trial. Reyes-Capo et al. The mean duration between COVID-19 vaccination and onset of ocular symptoms was 8.1 (range 213) days. He experienced left eye discomfort 13 days after vaccination. J Family Med Prim Care. official website and that any information you provide is encrypted AMN is a rare retinal disease, the pathophysiology of which is still unknown, although a microvascular abnormality in the deep capillary plexus of the retina is hypothesized.48,49 Of the AMN cases reviewed, all subjects were confounded by OCP usage. This site needs JavaScript to work properly. Several adverse events, including ocular manifestations, have been reported after vaccination. Annika Kim Constantino @annikakimc. On examination, there was no inflammation in either the anterior or vitreous cavities. A 33-year-old healthy Hispanic male referred to the ophthalmology service due to blurry vision and metamorphopsia in the right eye without any flashes, floaters, eye redness or pain. The central corneal thickness was 714 m, and corneal endothelial graft rejection was diagnosed. From conjunctivitis to vertigo, coronavirus infections can affect disparate senses. Bragazzi NL, Hejly A, Watad A, Adawi M, Amital H, Shoenfeld Y. ASIA syndrome and endocrine autoimmune disorders, Immune-mediated disease flares or new-onset disease in 27 subjects following mRNA/DNA SARS-CoV-2 vaccination, COVID-19 vaccines: modes of immune activation and future challenges, Type I interferon-mediated monogenic autoinflammation: the type I interferonopathies, a conceptual overview. The other case was a 67-year-old female who developed ecchymosis on the upper eyelids 10 days after the first dose of BNT162b2 COVID-19 vaccine. An mRNA Vaccine against SARS-CoV-2Preliminary Report. The coronavirus disease 2019 (COVID-19) pandemic has had profound and lasting consequences since 2019. Mambretti M, Huemer J, Torregrossa G, Ullrich M, Findl O, Casalino G. Acute macular neuroretinopathy following coronavirus disease 2019 vaccination. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (, Corneal graft rejection after penetrating keratoplasty (PKP), Corneal graft rejection after Descemet membrane endothelial keratoplasty (DMEK), Acute zonal occult outer retinopathy (AZOOR), Reactivation of Vogt-Koyanagi-Harada (VKH) Disease, Arteritic anterior ischemic optic neuropathy (AAION), Superior ophthalmic vein (SOV) thrombosis, Thrombocytopenia with acute ischemic stroke and bleeding, adverse events, coronavirus disease 2019 (COVID-19), ophthalmology, vaccines. Left eye posterior synechiae, AC cells, and KPs were noted. The COVID-19 vaccines included in these studies are mRNA vaccines and adenoviral vector vaccines, both of which do not contain the spike protein. A total of 341 studies were initially found after searching the databases according to the search strategy. Fundoscopy revealed subtle brightening around the fovea. IgG-ELISA for the PF4-heparin complex antibody was positive. Disclaimer. Regular eye injections. U.S. Food & Drug AdministrationCOVID-19 Vaccines. The visual acuity deficit lasted less than a day and was associated with a plethora of systemic nonspecific symptoms, such as unilateral headache, nausea, asthenia, and mild confusion. Funduscopic examination and autoimmune or infection lab screening did not reveal any alterations. Ocular Immunology and Inflammation, September 2021 Laboratory investigations revealed decreased platelet count and lack of fibrinogen. The .gov means its official. National Library of Medicine and Y.-H.H., who participated in management and interpretation of the data. Included studies were categorized in this study and divided based on the involved part of the eye. The literature research was conducted on 22 August 2021. Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine RecipientsUnited States, April 2021. Vaccinations in the autoimmune population decreases the burden of infection. The European Medicines Agency (EMA) and the US Food and Drug Administration have approved emergency use authorization for several COVID-19 vaccines before the completion of their clinical trials. OCT showed vitreous debris, retinal and choroidal thickening. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-dise 110-2628-B-006-018/Ministry of Science and Technology Taiwan, Lundstrom K., Barh D., Uhal B.D., Takayama K., Aljabali A.A.A., Abd El-Aziz T.M., Lal A., Redwan E.M., Adadi P., Chauhan G., et al. Of these 34, 19 (55.9%) were males, 15 (44.1%) were females, and the average age at the time of presentation was 47.6 16.3 years. Left eye ciliary injection, corneal edema, Descemet folds, and keratic precipitates (KP) were noted, and corneal graft rejection was diagnosed. NEW YORK (AP) The next round of COVID-19 vaccines will target one of the latest versions of the coronavirus, the Food and Drug Administration said Friday. The https:// ensures that you are connecting to the Right eye corneal edema, KPs, and AC cells were noted, and corneal graft rejection was diagnosed [14]. We used the following keywords for searching the databases: ((2019-nCoV OR nCoV-19 OR nCoV-2019 OR SARS-CoV-2 OR SARS-CoV2 OR SARSCoV2 OR SARS2 OR COVID OR coronavirus OR coronavirus disease 2019 OR severe acute respiratory syndrome) vaccine) AND (eye OR ocular OR oculopathy OR oculomotor OR intraocular OR extraocular OR ophthalmic OR vision OR orbit OR cornea OR conjunctiva OR retina OR sclera OR vitreous OR diplopia OR metamorphopsia OR visual OR optic)). The current literature shows substantial overlap between the ocular adverse effects of COVID-19 infection and COVID-19 vaccination. Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. Given the generally agreed incidence of Bells palsy at 1530 cases per 100,000 person-years,46,47 the median 2-month observation period of the clinical trials translated to an observed incidence of 3.57 times higher in the vaccine arms than the general population. Please enable it to take advantage of the complete set of features! reported that a middle-aged, previously healthy male developed a sudden onset of darkening of the visual field three days after receiving the second dose of BNT162b2 COVID-19 vaccine. Pandemic's impact on patients' eye health comes into focus To date, there is no evidence to suggest that individuals should avoid getting vaccinated for ophthalmic-related reasons. The newly approved vaccines are expected to be ready in the fall, a time when flu shots and updated COVID-19 shots also will be available. Go to: 2. The site is secure. One of the six patients had herpes zoster ophthalmicus without corneal involvement. But it's clear that some people with COVID experience inflammation throughout their body. The https:// ensures that you are connecting to the By 4 April 2021, 169 cases of CVST were reported among 34 million people vaccinated in the European Economic Area and United Kingdom with the ChAdO1 COVID-19 vaccine [48]. Although vaccines against COVID-19 have been developed and approved under emergency use authorization, various adverse events have also been reported after COVID-19 vaccination. New Covid vaccines in fall need to target XBB variants, FDA - CNBC Acute abducens nerve palsy following COVID-19 vaccination. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. COVID booster shots this fall to protect against newer virus strains The United States Food and Drug Administration (FDA) initially reported that the observed frequency of reported Bells palsy in the vaccine group was consistent with the expected background rate in the general population, providing no clear basis to conclude a causal relationship.44,45 Ozonoff et al.32 commented that such reporting was misconceived. Nevertheless, the described presentations resemble the reported ocular manifestations of the COVID-19 disease itself. -. Seventeen days after vaccination, she suddenly lost consciousness, and thrombocytopenia was noted. Ocular manifestations after receiving COVID-19 vaccines may appear on the eyelid, cornea and ocular surface, retina, uvea, nerve, and vessel. COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence? Infectious disease specialist strongly recommends getting updated COVID Biomolecules. Ocular adverse effects of COVID-19 vaccinations include facial nerve palsy, abducens nerve palsy, acute macular neuroretinopathy, central serous retinopathy, thrombosis, uveitis, multiple evanescent white dot syndrome, Vogt-Koyanagi-Harada disease reactivation, and new-onset Graves' Disease. Ocular Complications Following Vaccination for COVID-19: A One-Year An Israeli case-control study41 found that 21 of 37 individuals (56.8%) with facial nerve palsy were recently vaccinated with the first or second dose of the BNT162b2 vaccine, compared with 44 of 74 (59.5%) in the control group. In our literature review, there were seven patients who had retinal manifestations. 1 New research shows that Covid-19 causes eye problems, leading to hazy vision or black spots as the virus attacks the retina Credit: Getty On fluorescein angiography (FA), a single point of leakage was noted following the ink-blot pattern. Mean time between vaccination to uveitis onset was 7.57.3days (130days). It's like having specks of dust or dirt stuck to the lens of a . There were 19 patients with anterior uveitis whereas two patients were diagnosed to have multiple evanescent white dot syndrome (MEWDS) (after receiving the initial diagnosis of anterior uveitis). Loss of vision or changes like blank spots or flashes. The patients characteristics were reviewed from two articles. Careers, Unable to load your collection due to an error. Ramakrishnan MS, Patel AP, Melles R, Vora RA. Dias et al. adverse events; coronavirus disease 2019 (COVID-19); ophthalmology; vaccines. One year after COVID-19 and fighting for my vision | AOA Finally, 31 reports matched the inclusion criteria of our study. References cited within the identified articles were used to further augment the search. 8600 Rockville Pike He also developed light confusion, asthenia, and profound nausea [39]. [(accessed on 21 September 2021)]; Sahin U., Muik A., Derhovanessian E., Vogler I., Kranz L.M., Vormehr M., Baum A., Pascal K., Quandt J., Maurus D., et al. We also searched the references of the included studies for more relevant articles. All three patients purpuric eyelid lesions were asymptomatic and resolved spontaneously after 1015 days [11]. Indian J Ophthalmol. In our literature review, there were 12 patients with ocular manifestations. PRISMA flow diagram of the articles analyzed. Panovska-Stavridis et al. HHS Vulnerability Disclosure, Help doi: 10.1056/NEJMoa2022483. See et al. IgG-ELISA for the PF4-heparin complex antibody was positive, while CT venogram showed CVST. One case of severe anterior uveitis developed vitritis and macular edema following second vaccination, which needed and completely resolved following intravitreal dexamethasone.35. Fundus fluorescein angiography showed point leakage. reported a 71-year-old male with a history of endothelial decompensation after phacoemulsification and who underwent DMEK of the right eye for five months [15]. She had a history of well-controlled human immunodeficiency virus infection with undetectable viral load. Adenoviral vector vaccines, including ChAdO1chimpanzee adenovirus Y25 and Ad26.COV2.Shuman adenovirus 26, use replication-incompetent adenovirus as a vector to deliver the DNA signal sequence of spike protein [43,44]. Suresh et al. Acute macular neuroretinopathy: A comprehensive review of the literature. Association of Ocular Adverse Events With Inactivated COVID-19 Two review authors (Y.K.L. Problems after the second vaccine I thought were coincidence but now after having the virus both eyes have become . MRI showed thrombotic occlusion of the superior sagittal sinus and the left-hand transverse sinus and sigmoid sinus. However, the overall benefits of the COVID-19 vaccine in preventing COVID-19 are well established. MRI revealed a complete infarction in the entire area supplied by the right middle cerebral artery. Next round of COVID-19 shots in fall will target latest omicron strain The patient was prescribed spironolactone, and all symptoms eventually resolved on follow up. Epub 2022 Oct 14. 2022 Aug 1;12(4):465-471. doi: 10.4103/2211-5056.353129. In our literature review, there were three patients who developed neural manifestations. All were on oral contraceptive pills (OCP) and manifested symptoms two days after the first dose. Before The following day, she developed left-sided weakness and eye deviation to the right. Eric K., Lea K., Jenny R., Silvia B., Stefan K., Rolf M. Vaccine-Induced Covid-19 Mimicry Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines. Moreover, 15 cases of TTS were reported in the United States after administration of 7.98 million doses of Ad26.COV2.S COVID-19 vaccination during 2 March21 April 2021 [47]. Mercado N.B., Zahn R., Wegmann F., Loos C., Chandrashekar A., Yu J., Liu J., Peter L., McMahan K., Tostanoski L.H., et al. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. Wasser L.M., Roditi E., Zadok D., Berkowitz L., Weill Y. Keratoplasty Rejection After the BNT162b2 messenger RNA Vaccine. Bayas A, Menacher M, Christ M, Behrens L, Rank A, Naumann M. Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Ocular complications were reported in 74 unique individuals including facial nerve palsy/ Bells palsy, abducens nerve palsy, AMN, superior ophthalmic vein (SOV) thrombosis, corneal graft rejection, uveitis, central serous chorioretinopathy, VKH reactivation, and onset of Graves disease. Renisi G, Lombardi A, Stanzione M, Invernizzi A, Bandera A, Gori A. Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence? The patient reported that 69 hours prior to presentation he received the first dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine. For both DMEK cases, slit lamp examination and anterior segment optical coherence tomography (OCT) revealed moderate conjunctival injection, diffuse corneal oedema, and fine keratic precipitates limited to the donor endothelium with anterior chamber cells.
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